[HTML][HTML] The role of vascular cells in pancreatic beta-cell function

G Burganova, C Bridges, P Thorn… - Frontiers in …, 2021 - frontiersin.org
… of the cells in the pancreatic islets. Dysfunction of these cells … to encourage the islet
vascularisation required for basement … contact with intra-islet vascular endothelial cells or …

[HTML][HTML] Bioengineering the vascularized endocrine pancreas: a fine-tuned interplay between vascularization, extracellular-matrix-based scaffold architecture, and …

C Pignatelli, F Campo, A Neroni… - Transplant …, 2022 - frontierspartnerships.org
… transplanting allogeneic pancreas or pancreatic islets in T1D … hepatocyte growth factor
(HGF), vascular endothelial growth … rat lung left lobe to recreate a vascularized islet organ (VIO). …

Determinants and dynamics of pancreatic islet architecture

MT Adams, B Blum - Islets, 2022 - Taylor & Francis
… , hyper-vascularized, islets, though no change in overall islet … indicate that islet architecture
is important for optimal islet … of human pancreatic islets has implications for islet cell function. …

Islet vascularization is regulated by primary endothelial cilia via VEGF-A-dependent signaling

Y Xiong, MJ Scerbo, A Seelig, F Volta, N O'Brien… - Elife, 2020 - elifesciences.org
… in islet vascularization is vascular endothelial growth factor-A (VEGF-… the vascularization of
pancreatic islets. Importantly, there was … Here we suggest that there is an important, albeit not

The role of the islet niche on beta cell structure and function

E Lammert, P Thorn - Journal of molecular biology, 2020 - Elsevier
… The islets of Langerhans or pancreatic islets are pivotal in the … by vascular endothelial cells
(e) and the pericytes (p), the islet … too strong a vascularization at later time points of embryonic …

[HTML][HTML] A chronic fetal leucine infusion potentiates fetal insulin secretion and increases pancreatic islet size, vascularity, and β cells in late-gestation sheep

BH Boehmer, LD Brown, SR Wesolowski… - The Journal of …, 2020 - Elsevier
… leucine or vascular endothelial growth factor A (VEGFA) … insulin secretion from adult
pancreatic islets and β cells and … The other novel and important results from the current study …

A novel intron-encoded neuropilin-1 isoform in pancreatic islets associated with very young age of onset of type 1 diabetes

MJ MacDonald, IH Ansari, AS Riedemann… - Diabetes, 2022 - Am Diabetes Assoc
… Neuropilin-1 is a coreceptor for vascular endothelial growth … from vascularization (3–7).
The b1b2 domain of neuropilin-1 … We also show that in human pancreas the islet cells that

Beta-cell β1 integrin deficiency affects in utero development of islet growth and vascularization

PW Win, A Oakie, J Li, R Wang - Cell and tissue research, 2020 - Springer
… The findings from this study demonstrate that β1 integrin signaling is required during a … In
addition, vascular endothelial growth factor A (Vegf-a) production was not changed between …

Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes

B Qi, Y Ding, Y Zhang, L Kou, YZ Zhao, Q Yao - Biomaterials Science, 2024 - pubs.rsc.org
… The enhanced vascularization observed at the islet graft in … process, such as Vascular
Endothelial Growth Factor-A (VEGF-A… In this study, human pancreatic islets and human pluripotent …

Implications of integrated pancreatic microcirculation: crosstalk between endocrine and exocrine compartments

MP Dybala, LR Gebien, ME Reyna, Y Yu, M Hara - Diabetes, 2020 - Am Diabetes Assoc
growth factor A (VEGF-A) in the developing pancreas leads to reduced vascularization
and fenestration of islet capillaries (26). In the … Pancreatic islets and Gestalt principles …